Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …

Regulation of the opposing kinesin and dynein motors that drive axonal transport is
essential to maintain neuronal homeostasis. Here, we examine coordination of motor activity …

Kymographs are graphical representations of spatial position over time, which are often
used in biology to visualise the motion of fluorescent particles, molecules, vesicles, or …

Long-range retrograde axonal transport in neurons is driven exclusively by the microtubule
motor cytoplasmic dynein. The efficient initiation of dynein-mediated transport from the distal …

Bidirectional membrane trafficking along microtubules is mediated by kinesin-1, kinesin-3,
and dynein. Several organelle-bound adapters for kinesin-1 and dynein have been reported …

Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such
as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative …

During embryonic nervous system assembly, mRNA localization is precisely regulated in
growing axons, affording subcellular autonomy by allowing controlled protein expression in …

In axons, proper localization of proteins, vesicles, organelles, and other cargoes is
accomplished by the highly regulated coordination of kinesins and dyneins, molecular …

The endosomal system orchestrates the transport of lipids, proteins and nutrients across the
entire cell. Along their journey, endosomes mature, change shape via fusion and fission …