Experimental efforts to understand how the brain represents, stores and processes
information require high-fidelity recordings of multiple different forms of neural activity within …

In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Calcium imaging with protein-based indicators, is widely used to follow neural activity in
intact nervous systems, but current protein sensors report neural activity at timescales much …

High-grade gliomas are lethal brain cancers whose progression is robustly regulated by
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but …

Hippocampal neurons encode physical variables,,,,,–such as space or auditory frequency in
cognitive maps. In addition, functional magnetic resonance imaging studies in humans have …

INTRODUCTION Perceptual experiences in mammals may arise from patterns of neural
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …

The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …

Background Motion correction is a challenging pre-processing problem that arises early in
the analysis pipeline of calcium imaging data sequences. The motion artifacts in two-photon …

The combination of two-photon microscopy recordings and powerful calcium-dependent
fluorescent sensors enables simultaneous recording of unprecedentedly large populations …

Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer
time resolution. The resulting data rates require reproducible analysis pipelines that are …