Dengue
Dengue viruses have spread rapidly within countries and across regions in the past few
decades, resulting in an increased frequency of epidemics and severe dengue disease …
decades, resulting in an increased frequency of epidemics and severe dengue disease …
Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
Meta-and orthogonal integration of influenza “OMICs” data defines a role for UBR4 in virus budding
Several systems-level datasets designed to dissect host-pathogen interactions during
influenza A infection have been reported. However, apparent discordance among these …
influenza A infection have been reported. However, apparent discordance among these …
Zika virus targets human STAT2 to inhibit type I interferon signaling
The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as
emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome …
emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome …
Dengue virus and the host innate immune response
N Uno, TM Ross - Emerging microbes & infections, 2018 - Taylor & Francis
Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …
IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity
Dengue virus (DENV) infection in the presence of reactive, non-neutralizing immunoglobulin
G (IgG)(RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or dengue …
G (IgG)(RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or dengue …
Immune response to dengue and Zika
A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …
are human pathogens of global significance. In particular, DENV causes the most prevalent …
Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
Y Wu, Q Liu, J Zhou, W **e, C Chen, Z Wang, H Yang… - Cell discovery, 2017 - nature.com
Type I interferon (IFN) serves as the first line of defense against invading pathogens.
Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV …
Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV …
Innate immune evasion strategies of DNA and RNA viruses
Highlights•Viruses are sensed by host pattern recognition receptors during infection.•Viruses
must inhibit the innate antiviral immune response for full replication.•Viruses can sequester …
must inhibit the innate antiviral immune response for full replication.•Viruses can sequester …