Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade
inflammation is a substantial factor in its development and progression and has correlated …

Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

Over the past year, and for the first time ever, the US Food and Drug Administration
approved 2 drugs specifically for the treatment of lupus nephritis (LN). As the lupus …

There are several autoimmune and rheumatic diseases affecting different organs of the
human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly …

The development of omics technologies has driven a profound expansion in the scale of
biological data and the increased complexity in internal dimensions, prompting the …

BACKGROUND Proteinuria is considered an unfavorable clinical condition that accelerates
renal and cardiovascular disease. However, it is not clear whether all forms of proteinuria …

Background Novel urine biomarkers may improve identification of children at greater risk of
rapid kidney function decline, and elucidate the pathophysiology of CKD progression …

Background Childhood-onset chronic kidney disease is a progressive condition that can
have a major effect on life expectancy and quality. We evaluated the usefulness of the …

Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …

Effective management of chronic kidney disease (CKD), a major health problem worldwide,
requires accurate and timely diagnosis, prognosis of progression, assessment of therapeutic …