Written by the foremost authority in the field, this volume is a comprehensive review of the
multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between …

The aim of this study was to determine the optimal management of patients with
propylthiouracil (PTU) hepatotoxicity. A MEDLINE search for English language cases of PTU …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Intrahepatic cholestasis is the chemically induced syndrome characterized by biliary
retention without evidence of mechanical obstruction. The drugs known to have caused the …

Methimazole is a widely used and generally well-tolerated antithyroid agent. A 43-year-old
woman had severe jaundice and itching 1 month after receiving methimazole (10 mg tid) …

We review the cases of hepatic injury from propylthiouracil, methimazole and carbimazole in
the English language literature and compare them to cases of agranulocytosis in a recent …

Cholestatic jaundice caused by imidazole derivates is a rare complication of antithyroid
therapy. Only 20 such cases have been reported in the literature since the introduction of …

• A patient is described with cholestatic hepatitis following the use of carbimazole. A liver
biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate …

Close relationships exist between the liver and the thyroid. The liver is important in the
transport, metabolism, storage and excretion of thyroid hormones as well as being an …

Hepatotoxicity is well recognized with hormonal agents and their corresponding antagonists.
The spectrum of liver diseases associated with contraceptive steroids and anabolic …