A variety of targeted nanoparticles were developed for the diagnosis and therapy of
orthotopic and metastatic bone tumors during the past decade. This critical review will focus …

Magnetic Resonance Imaging is perhaps the most important and prominent technique in
diagnostic clinical medicine and biomedical research. Its success and development as an …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

The efficient delivery of nanomaterials to specific targets for in vivo biomedical imaging is
hindered by rapid sequestration by the reticuloendothelial system (RES) and consequent …

Calcium phosphate nanoparticles represent promising materials for drug delivery because
of its favorable properties, including biocompatibility, biodegradability and strong affinity for …

Abstract α, α-Bisphosphonates (BPs) are well established in the treatment of bone diseases
such as osteoporosis and Paget's disease. Their successful application originates from their …

The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

As a remarkable strategic resource, rare earth elements (REEs) endow implantable bone
regeneration materials with excellent properties both in vitro and in vivo, including …

Although bone tissues possess an intrinsic capacity for repair, there are cases where bone
healing is either impaired or insufficient, such as fracture non-union, osteoporosis …