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International union of pharmacology. XXIII. The angiotensin II receptors
M De Gasparo, KJ Catt, T Inagami, JW Wright… - Pharmacological …, 2000 - Elsevier
The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT 1 and AT
2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …
2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli
SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist
The first druglike selective angiotensin II AT2 receptor agonist (21) with a K i value of 0.4 nM
for the AT2 receptor and a K i> 10 μM for the AT1 receptor is reported. Compound 21, with a …
for the AT2 receptor and a K i> 10 μM for the AT1 receptor is reported. Compound 21, with a …
The renin–angiotensin system: a possible new target for depression
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention
has been given to the renin–angiotensin system. In the central nervous system, angiotensin …
has been given to the renin–angiotensin system. In the central nervous system, angiotensin …
Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity
C Liebmann - Cellular signalling, 2001 - Elsevier
G protein-coupled receptors (GPCRs) can stimulate the mitogen-activated protein kinase
(MAPK) cascade and thereby induce cellular proliferation like receptor tyrosine kinases …
(MAPK) cascade and thereby induce cellular proliferation like receptor tyrosine kinases …
Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain
Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …
Signal transduction from the angiotensin II AT2 receptor
S Nouet, C Nahmias - Trends in Endocrinology & Metabolism, 2000 - cell.com
Recent studies of genetically engineered animals have established a role for the
angiotensin II (AT 2) receptor in cardiovascular, renal and central functions, as well as in …
angiotensin II (AT 2) receptor in cardiovascular, renal and central functions, as well as in …
Calcium activation of ERK mediated by calmodulin kinase I
Elevated intracellular Ca 2+ triggers numerous signaling pathways including protein kinases
such as the calmodulin-dependent kinases (CaMKs) and the extracellular signal-regulated …
such as the calmodulin-dependent kinases (CaMKs) and the extracellular signal-regulated …
AT2 Receptor and Tissue Injury: Therapeutic Implications
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …