Using singlet oxygen to synthesize natural products and drugs

AA Ghogare, A Greer - Chemical reviews, 2016 - ACS Publications
This Review describes singlet oxygen (1O2) in the organic synthesis of targets on possible
1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for …

Continuous photo-oxidation in a vortex reactor: efficient operations using air drawn from the laboratory

DS Lee, Z Amara, CA Clark, Z Xu… - … process research & …, 2017 - ACS Publications
We report the construction and use of a vortex reactor which uses a rapidly rotating cylinder
to generate Taylor vortices for continuous flow thermal and photochemical reactions. The …

Applying green chemistry to the photochemical route to artemisinin

Z Amara, JFB Bellamy, R Horvath, SJ Miller, A Beeby… - Nature …, 2015 - nature.com
Artemisinin is an important antimalarial drug, but, at present, the environmental and
economic costs of its semi-synthetic production are relatively high. Most of these costs lie in …

Furans and singlet oxygen–why there is more to come from this powerful partnership

T Montagnon, D Kalaitzakis, M Triantafyllakis… - Chemical …, 2014 - pubs.rsc.org
The purpose of this article is to give a taste of just how powerful the union between furans
and photochemically-generated singlet oxygen is proving to be as a synthetic tool and to …

[HTML][HTML] Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

JM SOUZA, R Galaverna, AANDE Souza… - Anais da Academia …, 2018 - SciELO Brasil
We present a comprehensive review of the advent and impact of continuous flow chemistry
with regard to the synthesis of natural products and drugs, important pharmaceutical …

Wireless μLED packed beds for scalable continuous multiphasic photochemistry

ED Lopez, PZ Musacchio, AR Teixeira - Reaction Chemistry & …, 2024 - pubs.rsc.org
Photochemical and photocatalytic reactions are a powerful emerging tool in the green
synthesis of organic molecules. In contrast to thermochemical reactions, they promise …

Self-sensitized photooxidation of naphthols to naphthoquinones and the use of naphthoquinones as visible light photocatalysts in batch and continuous flow reactors

M Lancel, P Zimberlin, C Gomez, M Port… - The Journal of …, 2023 - ACS Publications
Visible light photooxidation of naphthols to produce naphthoquinones, such as the natural
product juglone, has been known for decades and has been widely utilized to benchmark …

Parallel microflow photochemistry: process optimization, scale-up, and library synthesis

A Yavorskyy, O Shvydkiv, N Hoffmann, K Nolan… - Organic …, 2012 - ACS Publications
A novel, multimicrocapillary flow reactor (MμCFR) was constructed and applied to a series of
sensitized photoadditions involving 2 (5 H)-furanones. The reactor allowed for rapid and …

Optimization of a scalable photochemical reactor for reactions with singlet oxygen

KN Loponov, J Lopes, M Barlog… - … Process Research & …, 2014 - ACS Publications
Oxygenation of α-pinene using photochemically generated singlet oxygen (1O2) was
studied in detail in several continuous flow photochemical reactors. Ferrioxalate actinometry …

A synergistic study on the synthesis of juglone via photooxidation in a UV–Vis LED based photomicroreactor

M Pasha, S Liu, M Shang, M Qiu, Y Su - Chemical Engineering Journal, 2022 - Elsevier
Photochemical transformations are mobilized by traceless photons of narrow or broad
visible light wavelength and have been proven as a green and sustainable synthesis route …