Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …

Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …

Heterocyclic scaffolds are frequently employed in drug development to treat a variety of
conditions, including cancers. These substances have the ability to engage covalently or …

With the significant growth of patients suffering from neurodegenerative diseases (NDs),
novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly …

Abstract A series of 1, 3, 5-trisubstituted-2-pyrazoline derivatives (3a–3t) were synthesized in
appreciable yields by substituting N1 position of 2-pyrazoline nucleus with 4 …

Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal fields.
Pyrazole is stable compound that is particularly used in pharmaceutical applications (ie …

Depression imposes a heavy burden on patients and society, and current antidepressants
often cause side effects such as dryness in the mouth and constipation. The explorations …

Polyethylene glycol-bonded triethylammonium L-prolinate ([PEG-TEA] LP) was prepared as
a new, highly efficient, reusable and biodegradable amino-acid-based ionic liquid catalyst …

The synthesis of 3, 5-disubstituted pyrazolines, integrated with heterocyclic systems,
represents a crucial area of chemical research due to their pharmacological and biological …

Nitrogen-containing organic compounds, in particular, heterocycles are of high importance
in numerous fields including the pharmaceutical and agrochemical industries. This review …