The roles of structural dynamics in the cellular functions of RNAs
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Cancers are caused by mutations that may be inherited, induced by environmental factors,
or result from DNA replication errors (R). We studied the relationship between the number of …
or result from DNA replication errors (R). We studied the relationship between the number of …
Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes
This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …
Quantum biology: An update and perspective
Understanding the rules of life is one of the most important scientific endeavours and has
revolutionised both biology and biotechnology. Remarkable advances in observation …
revolutionised both biology and biotechnology. Remarkable advances in observation …
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function
Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …
malfunctions can cause disease, it is necessary to describe their three-dimensional …
[HTML][HTML] Structural basis for Cas9 off-target activity
The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is
determined by complementarity to a 20-nucleotide segment in its guide RNA. However …
determined by complementarity to a 20-nucleotide segment in its guide RNA. However …
An open quantum systems approach to proton tunnelling in DNA
One of the most important topics in molecular biology is the genetic stability of DNA. One
threat to this stability is proton transfer along the hydrogen bonds of DNA that could lead to …
threat to this stability is proton transfer along the hydrogen bonds of DNA that could lead to …
DSSR: an integrated software tool for dissecting the spatial structure of RNA
Insight into the three-dimensional architecture of RNA is essential for understanding its
cellular functions. However, even the classic transfer RNA structure contains features that …
cellular functions. However, even the classic transfer RNA structure contains features that …
2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states
O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …
important biological roles through mechanisms that are not entirely understood. There is …