Clostridium perfringens causes many different histotoxic and enterotoxic diseases in
humans and animals as a result of its ability to produce potent protein toxins, many of which …

Members of the genus Clostridium are widely recognized as enteric pathogens of humans,
domestic animals, and wildlife (Tables 1 and 2). Their array of proven and putative virulence …

Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs
to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here …

Clostridium perfringens is a Gram-positive anaerobic spore-forming bacterium that causes
life-threatening gas gangrene and mild enterotoxaemia in humans, although it colonizes as …

A variety of pathogenic bacteria produce phospholipases C, and since the discovery in 1944
that a bacterial toxin (Clostridium perfringens alpha-toxin) possessed an enzymatic activity …

We determined the nucleotide sequence 3.8 kb upstream and 5.2 kb downstream of the
toxin genes A and B of Clostridium difficile. Nine ORFs were discovered. Based on PCR …

Necrotic enteritis is a disease in poultry that can have a high economic and animal welfare
cost, and has become increasingly prevalent in the European Union due to factors such as …

SUMMARY Type IV pili (T4P) are surface-exposed fibers that mediate many functions in
bacteria, including locomotion, adherence to host cells, DNA uptake (competence), and …

▪ Abstract Clostridium perfringens causes human gas gangrene and food poisoning as well
as several enterotoxemic diseases of animals. The organism is characterized by its ability to …

The pathogenesis of clostridial myonecrosis, or gas gangrene, involves the growth of the
anaerobic bacterium Clostridium perfringens in the infected tissues and the elaboration of …