For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral
hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in …

Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …

Background This study investigated the relationships of neutrophil count (NC), neutrophil-to-
lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small …

Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

Background and Objectives Previous studies suggest that lower mitochondrial DNA
(mtDNA) copy number (CN) is associated with neurodegenerative diseases. However …

Background Sodium-glucose cotransporter 2 (SGLT2) and SGLT1 inhibitors may have
additional beneficial metabolic effects on circulating metabolites beyond glucose regulation …

Background Previous genome-wide association studies (GWAS) have identified numerous
risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the …

APOE4 is the first identified genetic risk factor and remains as the strongest predictor for late-
onset Alzheimer's disease (AD). Studies of AD patients, AD patient-specific induced …

Background Stroke is a common neurological disorder that disproportionately affects middle-
aged and elderly individuals, leading to significant disability and mortality. Recently, human …