Pluronic F-68 and F-127 based nanomedicines for advancing combination cancer therapy

NU Khaliq, J Lee, S Kim, D Sung, H Kim - Pharmaceutics, 2023 - mdpi.com
Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene
oxide)(PEO) chains linked via a central hydrophobic polypropylene oxide (PPO). Owing to …

Therapeutic approaches in pancreatic cancer: recent updates

L Kumar, S Kumar, K Sandeep, SKS Patel - Biomedicines, 2023 - mdpi.com
Cancer is a significant challenge for effective treatment due to its complex mechanism,
different progressing stages, and lack of adequate procedures for screening and …

Breaking barriers: Nanomedicine-based drug delivery for cataract treatment

Y Chen, Z Ye, H Chen, Z Li - International Journal of Nanomedicine, 2024 - Taylor & Francis
Cataract is a leading cause of blindness globally, and its surgical treatment poses a
significant burden on global healthcare. Pharmacologic therapies, including antioxidants …

Strategies for Non-Covalent Attachment of Antibodies to PEGylated Nanoparticles for Targeted Drug Delivery

KW Ho, YL Liu, TY Liao, ES Liu… - International Journal of …, 2024 - Taylor & Francis
Polyethylene glycol (PEG)-modified nanoparticles (NPs) often struggle with reduced
effectiveness against metastasis and liquid tumors due to limited tumor cell uptake and …

Triethylamine-mediated protonation–deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis

L Lei, Y Song, L Yang, Y Wang, X **a, Y Zhang… - Proceedings of the …, 2025 - pnas.org
Carrier-free nanomedicines exhibited significant potential in elevating drug efficacy and
safety for tumor management, yet their self assembly typically relied on chemical …

Targeted internalization and activation of glycosidic switch liposomes by a biological macromolecule mPEG× EphA2 increases therapeutic efficacy against lung …

KW Ho, YL Liu, BC Huang, ST Hong, SH Yang… - International Journal of …, 2025 - Elsevier
Glycosidic switch liposome (GSL) technology efficiently encapsulates and stabilizes potent
anticancer drugs in liposomes using a reversible glucuronide ester. Enzymatic hydrolysis of …

Impact of doxorubicin-loaded ferritin nanocages (FerOX) vs. free doxorubicin on T lymphocytes: a translational clinical study on breast cancer patients undergoing …

M Sevieri, F Andreata, F Mainini, L Signati… - Journal of …, 2024 - Springer
Despite the advent of numerous targeted therapies in clinical practice, anthracyclines,
including doxorubicin (DOX), continue to play a pivotal role in breast cancer (BC) treatment …

Supramolecular-orchestrated carrier-free chemodynamic synergists with augmented oxidative damage for potentiated cancer therapy

X Meng, X Sun, Z Sun, Y Cheng, Y Wang, J Ye… - Chinese Chemical …, 2024 - Elsevier
ABSTRACT Metal ions trigger Fenton/Fenton-like reactions, generating highly toxic hydroxyl
radicals (• OH) for chemodynamic therapy (CDT), which is crucial in inducing lethal oxidative …

Green Synthesis of pH-Sensitive Carboxymethyl Cellulose/Agarose/Carbon Quantum Dots Nanocarriers for Quercetin Delivery to A549 Lung Cancer Using an …

M Pourmadadi, SM Shabestari, H Abdouss, Z Amiri… - BioNanoScience, 2024 - Springer
A novel pH-sensitive nanocarrier containing carboxymethyl cellulose (CMC), agarose (AG),
and carbon quantum dots (CQDs) was created using water/oil/water (W/O/W) emulsification …

HemoDL: Hemolytic peptides prediction by double ensemble engines from Rich sequence-derived and transformer-enhanced information

S Yang, P Xu - Analytical Biochemistry, 2024 - Elsevier
Hemolytic peptides can trigger hemolysis by rupturing red blood cells' membranes and
triggering cell disruption. Due to the labor-intensive and time-consuming in-lab identification …