Production of secondary metabolites using tissue culture-based biotechnological applications

II Ozyigit, I Dogan, A Hocaoglu-Ozyigit… - Frontiers in Plant …, 2023 - frontiersin.org
Plants are the sources of many bioactive secondary metabolites which are present in plant
organs including leaves, stems, roots, and flowers. Although they provide advantages to the …

Bioreactor-based advances in plant tissue and cell culture: challenges and prospects

A Valdiani, OK Hansen, UB Nielsen… - Critical reviews in …, 2019 - Taylor & Francis
Bioreactors are engineered systems capable of supporting a biologically active situation for
conducting aerobic or anaerobic biochemical processes. Stability, operational ease …

Bioreactor configurations for adventitious root culture: recent advances toward the commercial production of specialized metabolites

HN Murthy, KS Joseph, KY Paek… - Critical Reviews in …, 2024 - Taylor & Francis
In vitro plant cell and organ cultures are appealing alternatives to traditional methods of
producing valuable specialized metabolites for use as: pharmaceuticals, food additives …

Bioprocessing of differentiated plant in vitro systems

J Steingroewer, T Bley, V Georgiev… - Engineering in Life …, 2013 - Wiley Online Library
Plant cells contain a wide range of interesting secondary metabolites, which are used as
natural pigments and flavoring agents in foods and cosmetics as well as phyto …

Mass production of Ajmalicine by bioreactor cultivation of hairy roots of Catharanthus roseus

D Thakore, AK Srivastava, AK Sinha - Biochemical Engineering Journal, 2017 - Elsevier
Catharanthus roseus has been known to produce Ajmalicine which is used for treatment of
circulatory disorders. Significantly low content of the drug in the natural plant necessitates …

Enhanced Production of Artemisinin by Hairy Root Cultivation of Artemisia annua in a Modified Stirred Tank Reactor

N Patra, AK Srivastava - Applied biochemistry and biotechnology, 2014 - Springer
Artemisinin is an important drug commonly used in the treatment of malaria as a
combination therapy. It is primarily produced by a plant Artemisia annua, however, its supply …

Artemisinin production by plant hairy root cultures in gas-and liquid-phase bioreactors

N Patra, AK Srivastava - Plant cell reports, 2016 - Springer
Key message Alternative biotechnological protocol for large-scale artemisinin production
was established. It featured enhanced growth and artemisinin production by cultivation of …

Medicinal plant research at crossroads: biotechnological approaches for conservation, production and stability in tissue cultures and regenerated plants

M Halder, A Majumder, S Ray, S Jha - Medicinal Plants: Domestication …, 2021 - Springer
Medicinal plants are treasures of nature with almost never-ending resource of unlimited,
diverse, complex and valuable natural compounds with a variety of pharmacological …

Bioreactors for hairy roots culture: a review

SA Khan, MH Siddiqui, K Osama - Current Biotechnology, 2018 - ingentaconnect.com
Background: Plants are a source of a variety of secondary metabolites. Agrobacterium
rhizogenes mediated hairy root cultures offer a great advantage for the production of these …

Hairy root culture: bioreactor design and process intensification

AR Stiles, CZ Liu - Biotechnology of hairy root systems, 2013 - Springer
<? xm-replace_text {Heading}?> Abstract The cultivation of hairy roots for the production of
secondary metabolites offers numerous advantages; hairy roots have a fast growth rate, are …