In living organisms, proteins are regularly exposed to 'molecular ageing', which corresponds
to a set of non-enzymatic modifications that progressively cause irreversible damage to …

The identification of the mitochondrial contact site and cristae organizing system (MICOS) in
the inner mitochondrial membrane shed light on the intricate components necessary for …

Autophagy is a dynamic process which plays an important role in cellular homeostasis
through recycling of damaged proteins and organelles. Chronic hyperglycemia associated …

Skeletal muscle is a highly plastic tissue, able to change its mass and functional properties
in response to several stimuli. Skeletal muscle mass is influenced by the balance between …

The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of
the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a …

Type I diabetes mellitus (T1 DM) is a chronic disorder, characterized by an almost or
complete insulin deficiency. Widespread tissue dysfunction and deleterious diabetes …

Background Skeletal muscle wasting contributes to the poor functional status and quality of
life of patients with pulmonary arterial hypertension (PAH). The present study aims to …

Myocardial mitochondria dysfunction seems to represent an important pathogenic factor
underlying cardiomyopathy, a common complication of type 1 diabetes mellitus (T1DM) …

The mitochondrion is a vital organelle that performs diverse cellular functions. In this regard,
the cell has evolved various mechanisms dedicated to the maintenance of the mitochondrial …

ATP-dependent proteases are currently emerging as key regulators of mitochondrial
functions. Among these proteolytic systems, Lon protease is involved in the control of …