The paracaspase MALT1 has emerged as a key regulator of immune signaling, which also
promotes tumor development by both cancer cell-intrinsic and-extrinsic mechanisms. As an …

The main purpose of this review is to present justification for the urgent need to implement
specific prophylaxis of invasive Staphylococcus aureus infections. We emphasize the …

Inborn errors of immunity are traditionally best known for enhancing susceptibility to
infections. However, allergic inflammation, among other types of immune dysregulation …

With the improved quality of life, oral health is under increased pressure. Numerous
common oral mucosal diseases, such as oral lichen planus (OLP) and gingivitis, are related …

Purpose MALT1 deficiency is a combined immune deficiency characterized by recurrent
infections, eczema, chronic diarrhea, and failure to thrive. Clinical and immunological …

An innovative strategy for cancer therapy is to combine the inhibition of cancer cell-intrinsic
oncogenic signaling with cancer cell-extrinsic immunological activation of the tumor …

Nuclear factor kappa B (NF-κB) is a critical transcription factor involved in regulating cell
activation, inflammation, and survival. The linear ubiquitin chain assembly complex (LUBAC) …

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), a scaffold
protein, plays a pivotal role in the NF-κB pathway downstream of T-cell receptors (TCRs) …

Inborn errors of the CARD11-BCL10-MALT1 (CBM) signalosome have recently been shown
to underlie severe combined immunodeficiency (SCID) and combined immunodeficiency …

Fungi are opportunists: They particularly require a defect of immunity to cause severe or
disseminated disease. While often secondary to an apparent iatrogenic cause, fungal …