Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

All mucosal surfaces must deal with the challenge of exposure to the outside world. The
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …

Background Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with
heterogeneous clinical outcomes. Several molecular classifications have been proposed …

Abstract GATA binding protein 3 (GATA3) belongs to a family of transcription factors
comprising six members. These proteins identify GATA containing sequences in the target …

Introduction: GATA3 is a transcription factor involved in epithelial cell differentiation. GATA3
immunostaining is used as a diagnostic marker for breast and urothelial cancer but can also …

Understanding the molecular determinants that underpin the clinical heterogeneity of non-
muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy …

Introduction Murine models of urinary tract infection (UTI) have improved our understanding
of host-pathogen interactions. However, given differences between rodent and human …

Muscle-invasive bladder cancers are characterized by their distinct expression of luminal
and basal genes, which could be used to predict key clinical features such as disease …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in
diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA …