Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
R Drexler, F Brembach, J Sauvigny, FL Ricklefs… - Acta Neuropathologica …, 2024 - Springer
DNA methylation analysis has become a powerful tool in neuropathology. Although DNA
methylation-based classification usually shows high accuracy, certain samples cannot be …
methylation-based classification usually shows high accuracy, certain samples cannot be …
Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results
MGMT promoter methylation testing is required for prognosis and predicting temozolomide
response in gliomas. Accurate results depend on sufficient tumor cellularity, but histologic …
response in gliomas. Accurate results depend on sufficient tumor cellularity, but histologic …
The prognostic impact of subclonal IDH1 mutation in grade 2–4 astrocytomas
Background Isocitrate dehydrogenase (IDH) mutations are thought to represent an early
oncogenic event in glioma evolution, found with high penetrance across tumor cells; …
oncogenic event in glioma evolution, found with high penetrance across tumor cells; …
Pediatric-type high-grade gliomas with PDGFRA amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases
Y Kibe, F Ohka, K Aoki, J Yamaguchi… - Acta Neuropathologica …, 2024 - Springer
Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome
caused by heterozygous germline mutations or deletions in the TP53 tumor suppressor …
caused by heterozygous germline mutations or deletions in the TP53 tumor suppressor …
Enriched Methylomes of Low-input and Fragmented DNA Using Fragment Ligation EXclusive Methylation Sequencing (FLEXseq)
J Yu, LS Ahmann, YY Yao, W Gu - bioRxiv, 2024 - biorxiv.org
Methylome profiling is an emerging clinical tool for tumor classification and liquid biopsies.
Here, we developed FLEXseq, a genome-wide methylation profiler that enriches and …
Here, we developed FLEXseq, a genome-wide methylation profiler that enriches and …
[HTML][HTML] DNA Methylation-Based Classification of the Central Nervous System Tumors, Achievements, and Challenges
The classification, grading, and risk stratification of central nervous system (CNS) tumors
have rapidly evolved with the advent of integrative advanced molecular testing. Here, we …
have rapidly evolved with the advent of integrative advanced molecular testing. Here, we …