Long-term exposure to adverse life events that provoke acute or chronic psychological
stress (hereinafter “stress”) can negatively affect physical health and even increase …

Anxiety disorders (ADs) represent the sixth leading cause of disability worldwide, resulting in
a significant global economic burden. Over 50% of individuals with ADs do not respond to …

Ample evidence has suggested the stress etiology of depression, but the underlying
mechanism is not fully understood yet. Here, we report that chronic social defeat stress …

Neural activity in the claustrum has been associated with a range of vigilance states, yet the
activity patterns and efficacy of synaptic communication of identified claustrum neurons have …

Chronic social isolation increases the risk of mental health problems, including cognitive
impairments and depression. While subanesthetic ketamine is considered effective for …

Recent evidence indicates that neuronal activity within the claustrum (CLA) may be central
to cellular and behavioral responses to psychedelic hallucinogens. The CLA prominently …

Rationale: Recent evidence highlights the pivotal role of mitochondrial dysfunction in mood
disorders, but the mechanism involved remains unclear. We studied whether the …

Exposure to stressors has profound effects on sleep that have been linked to serotonin (5-
HT) neurons of the dorsal raphe nucleus (DR). However, the DR also comprises …

Major depressive disorder (MDD) is among the most common mental illnesses. Serotonergic
(5-HT) neurons are central to the pathophysiology and treatment of MDD. Repeatedly …

Stress can have severe psychological and physiological consequences. Thus, inappropriate
regulation of the stress response is linked to the etiology of mood and anxiety disorders. The …