Enzymes' power for plastics degradation

V Tournier, S Duquesne, F Guillamot… - Chemical …, 2023 - ACS Publications
Plastics are everywhere in our modern way of living, and their production keeps increasing
every year, causing major environmental concerns. Nowadays, the end-of-life management …

Mechanism-based design of efficient PET hydrolases

R Wei, G von Haugwitz, L Pfaff, J Mican… - ACS …, 2022 - ACS Publications
Polyethylene terephthalate (PET) is the most widespread synthetic polyester, having been
utilized in textile fibers and packaging materials for beverages and food, contributing …

Multiple substrate binding mode-guided engineering of a thermophilic PET hydrolase

L Pfaff, J Gao, Z Li, A Jäckering, G Weber… - ACS …, 2022 - ACS Publications
Thermophilic polyester hydrolases (PES-H) have recently enabled biocatalytic recycling of
the mass-produced synthetic polyester polyethylene terephthalate (PET), which has found …

Microbial enzymes will offer limited solutions to the global plastic pollution crisis

J Chow, P Perez‐Garcia, R Dierkes… - Microbial …, 2023 - Wiley Online Library
Global economies depend on the use of fossil‐fuel‐based polymers with 360–400 million
metric tons of synthetic polymers being produced per year. Unfortunately, an estimated 60 …

Structural insights into (tere) phthalate-ester hydrolysis by a carboxylesterase and its role in promoting PET depolymerization

G von Haugwitz, X Han, L Pfaff, Q Li, H Wei, J Gao… - ACS …, 2022 - ACS Publications
TfCa, a promiscuous carboxylesterase from Thermobifida fusca, was found to hydrolyze
polyethylene terephthalate (PET) degradation intermediates such as bis (2-hydroxyethyl) …

In vivo degradation of polyethylene terephthalate using microbial isolates from plastic polluted environment

B Maheswaran, M Al-Ansari, L Al-Humaid, JS Raj… - Chemosphere, 2023 - Elsevier
Accumulation of plastics alarms a risk to the environment worldwide. As polyethylene
pterephthalate (PET) degrades slowly and produces hazardous substances, therefore, it is …

Microbial enzyme biotechnology to reach plastic waste circularity: current status, problems and perspectives

M Orlando, G Molla, P Castellani, V Pirillo… - International Journal of …, 2023 - mdpi.com
The accumulation of synthetic plastic waste in the environment has become a global
concern. Microbial enzymes (purified or as whole-cell biocatalysts) represent emerging …

Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes

J Mican, J Da'san MM, W Liu, G Weber… - Applied Catalysis B …, 2024 - Elsevier
Polyethylene terephthalate (PET) is a widely used polyester due to its beneficial material
properties and low cost. However, PET contributes significantly to the growing problem of …

Discovery and genetic code expansion of a polyethylene terephthalate (PET) hydrolase from the human saliva metagenome for the degradation and bio …

B Eiamthong, P Meesawat, T Wongsatit… - Angewandte …, 2022 - Wiley Online Library
We report a bioinformatic workflow and subsequent discovery of a new polyethylene
terephthalate (PET) hydrolase, which we named MG8, from the human saliva metagenome …

High-throughput experimentation for discovery of biodegradable polyesters

KA Fransen, SHM Av-Ron, TR Buchanan… - Proceedings of the …, 2023 - pnas.org
The consistent rise of plastic pollution has stimulated interest in the development of
biodegradable plastics. However, the study of polymer biodegradation has historically been …