Prevalence and trends of advanced HIV disease among antiretroviral therapy-naive and antiretroviral therapy-experienced patients in South Africa between 2010 …
Background Despite the significant progress made in South Africa in getting millions of
individuals living with HIV into care, many patients still present or re-enter care with …
individuals living with HIV into care, many patients still present or re-enter care with …
[HTML][HTML] Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis
Objective: To estimate the prevalence of NRTI and NNRTI drug resistance mutations in
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …
Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research
A new first-line antiretroviral therapy (ART) regimen containing dolutegravir is being rolled
out in low-income and middle-income countries (LMICs). In studies from predominantly high …
out in low-income and middle-income countries (LMICs). In studies from predominantly high …
Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study
A Gupta-Wright, K Fielding, JJ van Oosterhout… - The Lancet …, 2020 - thelancet.com
Background Antiretroviral therapy (ART) scale-up in sub-Saharan Africa combined with
weak routine virological monitoring has driven increasing HIV drug resistance. We …
weak routine virological monitoring has driven increasing HIV drug resistance. We …
HIV drug resistance profile in South Africa: findings and implications from the 2017 national HIV household survey
Background HIV drug resistance (HIVDR) testing was included in the 2017 South African
national HIV household survey. We describe the prevalence of HIVDR by drug class, age …
national HIV household survey. We describe the prevalence of HIVDR by drug class, age …
Viral load testing and the use of test results for clinical decision making for HIV treatment in Cameroon: An insight into the clinic-laboratory interface
G Awungafac, ET Amin, A Fualefac, NF Takah… - PLoS …, 2018 - journals.plos.org
Background The viral load (VL) in patients receiving antiretroviral therapy (ART) is the best
predictor of treatment outcome. The anticipated benefits of VL monitoring depend on the …
predictor of treatment outcome. The anticipated benefits of VL monitoring depend on the …
Long‐term virologic responses to antiretroviral therapy among HIV‐positive patients entering adherence clubs in Khayelitsha, Cape Town, South Africa: a longitudinal …
Abstract Introduction: In South Africa, an estimated 4.6 million people were accessing
antiretroviral therapy (ART) in 2018. As universal Test and Treat is implemented, these …
antiretroviral therapy (ART) in 2018. As universal Test and Treat is implemented, these …
Lessons in diagnostic virology: expected and unexpected sources of error
Viral diagnostics have shown continued innovation, with serological and molecular
diagnostic assays pushing the limits of sensitivity. Technology has provided new automated …
diagnostic assays pushing the limits of sensitivity. Technology has provided new automated …
Drug resistance, rather than low tenofovir levels in blood or urine, is associated with tenofovir, emtricitabine, and efavirenz failure in resource-limited settings
The high cost of viral load (VL) testing limits its use for antiretroviral therapy (ART)
adherence support. A low-cost lateral flow urine tenofovir (TFV) rapid assay predicts pre …
adherence support. A low-cost lateral flow urine tenofovir (TFV) rapid assay predicts pre …
Urine tenofovir-monitoring predicts HIV viremia in patients treated with high genetic-barrier regimens
Objective: Access to viral load measurements is constrained in resource-limited settings. A
lateral flow urine tenofovir (TFV) rapid assay (UTRA) for patients whose regimens include …
lateral flow urine tenofovir (TFV) rapid assay (UTRA) for patients whose regimens include …