The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The investigation of biological processes by chemical methods, commonly referred to as
chemical biology, often requires chemical access to biologically relevant macromolecules …

Transition metal catalysis plays a central role in contemporary organic synthesis.
Considering the tremendously broad array of transition metal–catalyzed transformations, it is …

The chemical synthesis of homogeneously modified histones is a powerful approach to
quantitatively decipher how post-translational modifications (PTMs) modulate epigenetic …

Quasi-racemic crystallography has been used to determine the X-ray structures of K27-
linked ubiquitin (Ub) chains prepared through total chemical synthesis. Crystal structures of …

Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

Among the techniques employed for coupling peptide segments,[1] native chemical ligation
is among the most useful.[2] Since its discovery it has become a powerful tool for the …

Glycans are ubiquitous components of all organisms. Efforts to elucidate glycan function and
to understand how they are assembled and disassembled can reap benefits in fields …

A number of recent advances in the chemical synthesis of glycopeptides and glycoproteins
are described, with particular focus on the development of peptide ligation strategies and …

Native chemical ligation enables the chemical synthesis of proteins. Previously, thiol‐
containing auxiliary groups have been used to extend the reaction scope beyond N‐terminal …