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Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation
Human interferon gamma is a cytokine belonging to a diverse group of interferons which
have a crucial immunological function against mycobacteria and a wide variety of viral …
have a crucial immunological function against mycobacteria and a wide variety of viral …
Trace metals in cellular metabolism and their impact on recombinant protein production
Replacement of serum and increasing use of chemically defined media demands
optimisation of trace metal components for biomanufacturing applications. Trace metal …
optimisation of trace metal components for biomanufacturing applications. Trace metal …
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth …
M Jang, ES Pete, P Bruheim - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Serum-free cultures are preferred for application in clinical cell therapy and facilitate the
purification processes of bioproducts, such as vaccines and recombinant proteins. It can …
purification processes of bioproducts, such as vaccines and recombinant proteins. It can …
A review: Analysis of technical challenges in cultured meat production and its commercialization
YY Zheng, ZN Hu, GH Zhou - Critical Reviews in Food Science and …, 2024 - Taylor & Francis
The cultured meat technology has developed rapidly in recent years, but there are still many
technical challenges that hinder the large-scale production and commercialization of …
technical challenges that hinder the large-scale production and commercialization of …
Biosensors for waterborne viruses: Detection and removal
Detection of waterborne viruses is important to eliminate and control their harmful effect as
pathogens. Hence, the use of rapid and sensitive detection technologies is critically …
pathogens. Hence, the use of rapid and sensitive detection technologies is critically …
Application of multi-omics techniques for bioprocess design and optimization in Chinese hamster ovary cells
A Farrell, N McLoughlin, JJ Milne… - Journal of proteome …, 2014 - ACS Publications
Significant improvements in the productivity and quality of therapeutic proteins produced in
Chinese hamster ovary (CHO) cells have been reported since their establishment as host …
Chinese hamster ovary (CHO) cells have been reported since their establishment as host …
Miniaturized single-cell technologies for monoclonal antibody discovery
Antibodies (Abs) are among the most important class of biologicals, showcasing a high
therapeutic and diagnostic value. In the global therapeutic Ab market, fully-human …
therapeutic and diagnostic value. In the global therapeutic Ab market, fully-human …
[HTML][HTML] Transcriptomic changes in CHO cells after adaptation to suspension growth in protein-free medium analysed by a species-specific microarray
S Shridhar, G Klanert, N Auer, I Hernandez-Lopez… - Journal of …, 2017 - Elsevier
Abstract Chinese Hamster Ovary (CHO) cells are the preferred cell line for production of
biopharmaceuticals. These cells are capable to grow without serum supplementation, but …
biopharmaceuticals. These cells are capable to grow without serum supplementation, but …
The bioactivity and fractionation of peptide hydrolysates in cultures of CHO cells
M Spearman, C Lodewyks, M Richmond… - Biotechnology …, 2014 - Wiley Online Library
Peptide hydrolysate supplements in mammalian cell cultures provide enhanced growth and
productivity. The objective of this study was to compare the bioactivity of ten different …
productivity. The objective of this study was to compare the bioactivity of ten different …
Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells
The glutamine synthetase (GS) expression system is commonly used to ensure stable
transgene integration and amplification in Chinese hamster ovary (CHO) host lines …
transgene integration and amplification in Chinese hamster ovary (CHO) host lines …