Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A
key modulator of this disease is nocturnal intermittent hypoxia. There is striking …

Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …

Organs-on-chips have the potential to improve drug development efficiency and decrease
the need for animal testing. For the successful integration of these devices in research and …

Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …

One of the most arduous challenges in tissue engineering is neovascularization, without
which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be …

Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably
causing decreased breathing capacity and quality of life for patients. While animal models …

In the last decade, the advent of microfabrication and microfluidics and an increased interest
in cellular mechanobiology have triggered the development of novel microfluidic-based …

The aim of this review is to provide a systematic design guideline to users, particularly
engineers interested in develo** and deploying lung models, and biologists seeking to …

Drug discovery and toxicology is a complex process that involves considerable basic
research and preclinical evaluation. These depend highly on animal testing which often fails …

Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator‐
induced) conditions is known to significantly impact all cellular compartments in the lung …