Genotype–Phenotype relationships in the context of transcriptional adaptation and genetic robustness
G Jakutis, DYR Stainier - Annual review of genetics, 2021 - annualreviews.org
Genetic manipulations with a robust and predictable outcome are critical to investigate gene
function, as well as for therapeutic genome engineering. For many years, knockdown …
function, as well as for therapeutic genome engineering. For many years, knockdown …
The role of structure in regulatory RNA elements
JN Tants, A Schlundt - Bioscience reports, 2024 - portlandpress.com
Regulatory RNA elements fulfill functions such as translational regulation, control of
transcript levels, and regulation of viral genome replication. Trans-acting factors (ie, RNA …
transcript levels, and regulation of viral genome replication. Trans-acting factors (ie, RNA …
Probabilistic transformer: Modelling ambiguities and distributions for rna folding and molecule design
Our world is ambiguous and this is reflected in the data we use to train our algorithms. This
is particularly true when we try to model natural processes where collected data is affected …
is particularly true when we try to model natural processes where collected data is affected …
Experimental demonstration and pan-structurome prediction of climate-associated riboSNitches in Arabidopsis
Background Genome-wide association studies (GWAS) aim to correlate phenotypic changes
with genotypic variation. Upon transcription, single nucleotide variants (SNVs) may alter …
with genotypic variation. Upon transcription, single nucleotide variants (SNVs) may alter …
Synonymous variants that disrupt messenger RNA structure are significantly constrained in the human population
Background The role of synonymous single-nucleotide variants in human health and
disease is poorly understood, yet evidence suggests that this class of “silent” genetic …
disease is poorly understood, yet evidence suggests that this class of “silent” genetic …
Synonymous variants: necessary nuance in our understanding of cancer drivers and treatment outcomes
NM Kaissarian, D Meyer… - Journal Of The National …, 2022 - academic.oup.com
Once called “silent mutations” and assumed to have no effect on protein structure and
function, synonymous variants are now recognized to be drivers for some cancers. There …
function, synonymous variants are now recognized to be drivers for some cancers. There …
Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the fibroblast growth factor 21 locus
Abstract Fibroblast growth factor 21 (FGF21) is a liver‐derived hormone with pleiotropic
beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic …
beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic …
[HTML][HTML] In-Silico analysis reveals lower transcription efficiency of C241T variant of SARS-CoV-2 with host replication factors MADP1 and hnRNP-1
Novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has claimed more
than 3.3 million lives worldwide and still counting. As per the GISAID database, the …
than 3.3 million lives worldwide and still counting. As per the GISAID database, the …
LncRNA GAS8-AS1 dinucleotide genetic variantn.713A>G, n.714T>C is associated with early-stage disease, lymph node, and distant metastasis in differentiated …
Abstract Purpose Long noncoding RNAs (lncRNAs) play an essential role in the epigenetic
regulation of various key genes involved in vital cellular functions. A somatic dinucleotide …
regulation of various key genes involved in vital cellular functions. A somatic dinucleotide …
Tumour mutations in long noncoding RNAs enhance cell fitness
Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their
expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell …
expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell …