The type I interferonopathies: 10 years on
As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …
Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
Management strategies and future directions for systemic lupus erythematosus in adults
Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …
ADAR1 mutation causes ZBP1-dependent immunopathology
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …
Interferons and proinflammatory cytokines in pregnancy and fetal development
Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …
New insights into the immunopathogenesis of systemic lupus erythematosus
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …
Signaling by cGAS–STING in neurodegeneration, neuroinflammation, and aging
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient
Objective Autoimmune encephalitis (AE) is an important and treatable cause of acute
encephalitis. Diagnosis of AE in a develo** child is challenging because of overlap in …
encephalitis. Diagnosis of AE in a develo** child is challenging because of overlap in …
Discriminating self from non-self in nucleic acid sensing
Innate immunity against pathogens relies on an array of immune receptors to detect
molecular patterns that are characteristic of the pathogens, including receptors that are …
molecular patterns that are characteristic of the pathogens, including receptors that are …