Although it has become routine to consider DNA in terms of its role as a carrier of genetic
information, it is also an important contributor to the control of gene expression. This …

Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …

As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information
is generally carried on a circular chromosome with a single origin of replication from which …

Liquid-liquid phase-separated (LLPS) states are key to compartmentalizing components in
the absence of membranes; however, it is unclear whether LLPS condensates are actively …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

Gepotidacin is a first-in-class triazaacenaphthylene novel bacterial topoisomerase inhibitor
(NBTI). The compound has successfully completed phase II trials for the treatment of acute …

Structural maintenance of chromosomes (SMC) complexes organize chromosomes
ubiquitously, thereby contributing to their faithful segregation. We demonstrate that under …

Cells are continuously facing the risk of taking up foreign DNA that can compromise
genomic integrity. Therefore, bacteria are in a constant arms race with mobile genetic …

Despite their diverse biochemical characteristics and functions, all DNA-binding proteins
share the ability to accurately locate their target sites among the vast excess of non-target …

Since the nucleoid was isolated from bacteria in the 1970s, two fundamental questions
emerged and are still in the spotlight: how bacteria organize their chromosomes to fit inside …