Innate immune system activation, inflammation and corneal wound healing

N Fortingo, S Melnyk, SH Sutton, MA Watsky… - International journal of …, 2022 - mdpi.com
Corneal wounds resulting from injury, surgeries, or other intrusions not only cause pain, but
also can predispose an individual to infection. While some inflammation may be beneficial to …

Updated perspectives on keratinocytes and psoriasis: keratinocytes are more than innocent bystanders

LI Ortiz-Lopez, V Choudhary… - Psoriasis: Targets and …, 2022 - Taylor & Francis
Psoriasis is a complex disease triggered by genetic, immunologic, and environmental
stimuli. Many genes have been linked to psoriasis, like the psoriasis susceptibility genes …

The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs

ST LoPresti, ML Arral, N Chaudhary… - Journal of Controlled …, 2022 - Elsevier
The broad clinical application of mRNA therapeutics has been hampered by a lack of
delivery vehicles that induce protein expression in extrahepatic organs and tissues …

Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis

N Lian, Y Chen, S Chen, Y Zhang, H Chen… - Cell Death & …, 2023 - nature.com
Gasdermin D (GSDMD)-mediated pyroptosis has a significant pro-inflammation
characteristic due to dramatic secretion of pro-inflammatory substances. However, its role …

[HTML][HTML] DAMPs in immunosenescence and cancer

F Chen, H Tang, X Cai, J Lin, R Kang, D Tang… - Seminars in Cancer …, 2024 - Elsevier
Damage-associated molecular patterns (DAMPs) are endogenous molecules released by
cells in response to injury or stress, recognized by host pattern recognition receptors that …

Aquaporin-3 in the epidermis: more than skin deep

WB Bollag, L Aitkens, J White… - American Journal of …, 2020 - journals.physiology.org
The skin is essential for terrestrial life. It is responsible for regulating water permeability and
functions as a mechanical barrier that protects against environmental insults such as …

Fat of the gut: epithelial phospholipids in inflammatory bowel diseases

LV Boldyreva, MV Morozova, SS Saydakova… - International journal of …, 2021 - mdpi.com
Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

Long-term chronic food-derived arsenic exposure induce the urinary system metabolic dysfunction in mice

Z Huang, L Guo, X Chen, J Sun, Y Ye, L Sheng… - Science of the Total …, 2023 - Elsevier
The consumption of rice contaminated with arsenic on a long-term basis has emerged as a
pressing public health issue of global significance. Arsenic-induced urinary injury …

High-confidence structural annotation of substances via multi-layer molecular network reveals the system-wide constituent alternations in milk interfered with …

Z Fan, W Jia - Journal of Hazardous Materials, 2024 - Elsevier
The spectral database-based mass spectrometry (MS) matching strategy is versatile for
structural annotating in ingredient fluctuation profiling mediated by external interferences …

[HTML][HTML] Luteolin attenuates imiquimod–induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response

W Zhou, M Hu, X Zang, Q Liu, J Du, J Hu… - Biomedicine & …, 2020 - Elsevier
Psoriasis is considered as a common chronic immune-mediated skin disorder characterized
by abnormal keratinocyte proliferation. Luteolin, an anti-inflammatory natural flavonoid with …