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De novo protein design, a retrospective
Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …
complex folds with precisely defined structural and dynamic properties. The rational design …
De novo metalloprotein design
Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …
and catalysis—in which the position and property of each ligand and metal are dictated by …
Protein design: toward functional metalloenzymes
Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …
protein structure and function. The field of protein design has seen significant progress over …
Catalysis and Electron Transfer in De Novo Designed Metalloproteins
One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …
in our ability to design new, non-native, catalytically active protein scaffolds. This review …
De novo design of four-helix bundle metalloproteins: One scaffold, diverse reactivities
A Lombardi, F Pirro, O Maglio, MT Zimmerman, CA Bayse, RR Ramoutar… - Journal of inorganic …, 2015 - Elsevier
Because sulfur and selenium antioxidants can prevent oxidative damage, numerous animal
and clinical trials have investigated the ability of these compounds to prevent the oxidative …
and clinical trials have investigated the ability of these compounds to prevent the oxidative …