[HTML][HTML] Metabolome analysis for investigating host-gut microbiota interactions

MX Chen, SY Wang, CH Kuo, IL Tsai - Journal of the Formosan Medical …, 2019 - Elsevier
Dysbiosis of the gut microbiome is associated with host health conditions. Many diseases
have shown to have correlations with imbalanced microbiota, including obesity …

Systematic review of prediction models for pulmonary tuberculosis treatment outcomes in adults

LS Peetluk, FM Ridolfi, PF Rebeiro, D Liu, VC Rolla… - BMJ open, 2021 - bmjopen.bmj.com
Objective To systematically review and critically evaluate prediction models developed to
predict tuberculosis (TB) treatment outcomes among adults with pulmonary TB. Design …

Biomarker discovery for tuberculosis using metabolomics

Y Yu, XX Jiang, JC Li - Frontiers in molecular biosciences, 2023 - frontiersin.org
Tuberculosis (TB) is the leading cause of death among infectious diseases, and the ratio of
cases in which its pathogen Mycobacterium tuberculosis (Mtb) is drug resistant has been …

The echo of pulmonary tuberculosis: mechanisms of clinical symptoms and other disease-induced systemic complications

L Luies, I Du Preez - Clinical microbiology reviews, 2020 - journals.asm.org
Clinical symptoms of active tuberculosis (TB) can range from a simple cough to more severe
reactions, such as irreversible lung damage and, eventually, death, depending on disease …

Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis

D Magdalena, S Michal, S Marta, KP Magdalena… - Scientific reports, 2022 - nature.com
Profound tuberculosis (TB)-induced metabolic changes reflected in the blood metabolomic
profile may provide an opportunity to identify specific markers of Mycobacterium tuberculosis …

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children

NK Dutta, JA Tornheim, KF Fukutani, M Paradkar… - Scientific reports, 2020 - nature.com
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric
diagnostics using readily available biosources are urgently needed. We used liquid …

Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus

AA Adeniji, KE Knoll, DT Loots - Applied microbiology and biotechnology, 2020 - Springer
The latest WHO report estimates about 1.6 million global deaths annually from TB, which is
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …

Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry

L Zhou, D Yu, S Zheng, R Ouyang, Y Wang… - TrAC Trends in Analytical …, 2021 - Elsevier
Gut microbiota can either contribute to the host development and health, or lead to the
pathogenesis of various diseases in the case of imbalance. Microbial metabolites can act as …

Metabolic insights into HIV/TB co-infection: an untargeted urinary metabolomics approach

C Olivier, L Luies - Metabolomics, 2024 - Springer
Introduction Amid the global health crisis, HIV/TB co-infection presents significant
challenges, amplifying the burden on patients and healthcare systems alike. Metabolomics …

In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis

KE Knoll, MM van der Walt, DT Loots - Microbiology Spectrum, 2022 - journals.asm.org
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics
and the high costs for clinical trials, hampers the development of novel antimicrobial agents …