Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive dysfunction and behavioral impairment. The typical …

The impact of Alzheimer's disease (AD) on the pupillary light response (PLR) is
controversial, being dependent on the stage of the disease and on the experimental …

Pupil size variations have been associated with changes in brain activity patterns related
with specific cognitive factors, such as arousal, attention, and mental effort. The locus …

Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …

Quantitative pupillometry provides a noninvasive and objective assessment within the
neurological examination. This review details the physiology of the pupillary light response …

Eye tracking (ET) studies are becoming increasingly popular due to rapid methodological
and technological advances as well as the development of cost efficient and portable eye …

Acetylcholine (ACh) is thought to play a role in driving the rapid, spontaneous brain-state
transitions that occur during wakefulness; however, the spatiotemporal properties of cortical …

Pupil dynamics has emerged as a critical non-invasive indicator of brain state changes. In
particular, pupillary-light-responses (PLR) in Alzheimer's disease (AD) patients show …

Pupillary light reflex (PLR) assessment is a crucial examination for evaluating brainstem
function, particularly in patients with acute brain injury and neurosurgical conditions. The …

Background Melanopsin-expressing retinal ganglion cells (mRGCs), intrinsically
photosensitive RGCs, mediate the light-based pupil response and the light entrainment of …