Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the central nervous system. The LC-NE system has a major …

Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …

Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin
(5HT) neurotransmitter systems in depression and anxiety disorders. The majority of …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …

In Parkinson's disease (PD), in addition to degeneration of the nigrostriatal dopaminergic
pathway, a variety of neuronal systems are involved, causing multiple neuromediator …

In Parkinson's disease, rapid eye movement sleep behaviour disorder is an early non-
dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid …

The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …