Background A systematic understanding of how multimorbidity has been constructed and
measured is unavailable. This review aimed to examine the definition and measurement of …

Introduction: Polypharmacy, the use of multiple medications by one individual, is
increasingly common among older adults. Caring for the growing number of older people …

Background Multimorbidity and frailty are complex syndromes characteristics of aging. We
reviewed the literature and provided pooled estimations of any evidence regarding (a) the …

Objective Polypharmacy is the concomitant use of several drugs by a single person, and it
increases the risk of adverse drug-related events in older adults. Little is known about the …

Introduction Diabetes is a well‐established risk factor for dementia, but its impact on the
prodromal phase of dementia is unclear. Methods Cohorts of older adults who were …

Background Multimorbidity is defined as the presence of multiple chronic conditions in the
same individual. Multimorbidity is more prevalent in older adults and can lead to several …

Multimorbidity—the co-occurrence of multiple diseases—is associated to poor prognosis,
but the scarce knowledge of its development over time hampers the effectiveness of clinical …

Abstract Purpose Adverse drug reactions (ADRs) represent a common and potentially
preventable cause of unplanned hospitalization, increasing morbidity, mortality, and …

Life expectancy is increasing and so is the prevalence of age-related non-communicable
diseases (NCDs). Consequently, older people and patients present with multi-morbidities …

Importance Emerging yet contrasting evidence associates air pollution with incident
dementia, and the potential role of cardiovascular disease (CVD) in this association is …