There has been considerable recent progress in protein structure prediction using deep
neural networks to predict inter-residue distances from amino acid sequences,–. Here we …

X-ray diffraction patterns from crystals of biological macromolecules contain sufficient
information to define atomic structures, but atomic positions are inextricable without having …

Degeneracy in the genetic code, which enables a single protein to be encoded by a
multitude of synonymous gene sequences, has an important role in regulating protein …

Aggregation can be thought of as a form of protein folding in which intermolecular
associations lead to the formation of large, insoluble assemblies. Various types of …

Abstract The Protein Model Portal (PMP) has been developed to foster effective use of 3D
molecular models in biomedical research by providing convenient and comprehensive …

Active sites and ligand-binding cavities in native proteins are often formed by curved β
sheets, and the ability to control β-sheet curvature would allow design of binding proteins …

Comparative protein structure modeling is a computational approach to build three-
dimensional structural models for proteins using experimental structures of related protein …

Antibodies are key reagents in biology and medicine, but commercial sources are rarely
recombinant and thus do not provide a permanent and renewable resource. Here, we …

Motivation Recombinant protein production is a widely used technique in the biotechnology
and biomedical industries, yet only a quarter of target proteins are soluble and can therefore …

Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and
inflammation. In addition, prophylactic use of acetylsalicylic acid, commonly known as …