Fluid transport in the brain
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
The glymphatic system: implications for drugs for central nervous system diseases
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …
known as the glymphatic system has grown. According to the glymphatic system concept …
[HTML][HTML] Functional characterization of the dural sinuses as a neuroimmune interface
Despite the established dogma of central nervous system (CNS) immune privilege,
neuroimmune interactions play an active role in diverse neurological disorders. However …
neuroimmune interactions play an active role in diverse neurological disorders. However …
Physiological blood–brain transport is impaired with age by a shift in transcytosis
The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …
A mesothelium divides the subarachnoid space into functional compartments
The central nervous system is lined by meninges, classically known as dura, arachnoid, and
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …
Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
Interactions between the immune and central nervous systems strongly influence brain
health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal …
health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal …
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
H Mestre, LM Hablitz, ALR Xavier, W Feng, W Zou… - Elife, 2018 - elifesciences.org
The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the
accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression …
accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression …
Cerebrospinal fluid influx drives acute ischemic tissue swelling
INTRODUCTION Cerebrospinal fluid (CSF) covers and protects the brain from mechanical
injury. CSF also flows along an interconnected network of perivascular spaces surrounding …
injury. CSF also flows along an interconnected network of perivascular spaces surrounding …
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …
Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice
BK Mathiesen, LM Miyakoshi, CR Cederroth… - Science translational …, 2023 - science.org
Inner ear gene therapy has recently effectively restored hearing in neonatal mice, but it is
complicated in adulthood by the structural inaccessibility of the cochlea, which is embedded …
complicated in adulthood by the structural inaccessibility of the cochlea, which is embedded …