The re-emergence of natural products for drug discovery in the genomics era
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …
use has diminished in the past two decades, in part because of technical barriers to …
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …
the living beings chemistry. However, identification of drugable molecules within the …
Dereplication: racing to speed up the natural products discovery process
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …
Current status and contemporary approaches to the discovery of antitumor agents from higher plants
G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …
both chemically unmodified small molecules and their synthetic derivatives currently used or …
Combined LC/UV/MS and NMR strategies for the dereplication of marine natural products
I Pérez-Victoria, J Martín, F Reyes - Planta medica, 2016 - thieme-connect.com
Drug discovery from marine natural products has experienced a revival since the beginning
of this century. To be successful in this field, rapid dereplication (identification of already …
of this century. To be successful in this field, rapid dereplication (identification of already …
The integration of LC‐MS and NMR for the analysis of low molecular weight trace analytes in complex matrices
This review discusses the integration of liquid chromatography (LC), mass spectrometry
(MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small …
(MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small …
Recent advances and new strategies in the NMR-based identification of natural products
Highlights•Natural products are advancing a dynamic comeback in drug
discovery.•Advances in NMR play a vital role in the identification of natural products.• …
discovery.•Advances in NMR play a vital role in the identification of natural products.• …
Trap**‐enrichment multi‐dimensional liquid chromatography with on‐line deuterated solvent exchange for streamlined structure elucidation at the microgram scale
At the forefront of chemistry and biology research, development timelines are fast‐paced
and large quantities of pure targets are rarely available. Herein, we introduce a new …
and large quantities of pure targets are rarely available. Herein, we introduce a new …
Dereplication of microbial extracts and related analytical technologies
T Ito, M Masubuchi - The Journal of antibiotics, 2014 - nature.com
Natural products still continue to have an important role as a resource of various biologically
active substances. Dereplication is a key process in natural product screening that analyzes …
active substances. Dereplication is a key process in natural product screening that analyzes …
Chromatographic analysis with different detectors in the chemical characterisation and dereplication of African propolis
Propolis or bee glue has very diverse composition and is potentially a source of biologically
active compounds. Comprehensive chemical profiling was performed on 22 African propolis …
active compounds. Comprehensive chemical profiling was performed on 22 African propolis …