Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic
cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive …

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

Extending the success of cellular immunotherapies against blood cancers to the realm of
solid tumors will require improved in vitro models that reveal therapeutic modes of action at …

Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a
binary,“yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill …

Among the caspases that cause regulated cell death, a unique function for caspase-7 has
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …

Chimeric antigen receptors (CARs) are synthetic antigen receptors that reprogram T cell
specificity, function and persistence. Patient-derived CAR T cells have demonstrated …

Effector T cells have the capability of recognizing and killing cancer cells. However, whether
tumors can become immune resistant through exclusion of effector T cells from the tumor …

Cytotoxic T lymphocytes (CTLs) and natural killer cells kill virus-infected and tumor cells
through the polarized release of perforin and granzymes. Perforin is a pore-forming toxin …

The immune system can suppress tumour development both by eliminating malignant cells
and by preventing the outgrowth and spread of cancer cells that resist eradication. Clinical …

Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly
pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it …