Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

Gene expression is regulated by transcription factors (TFs), proteins that recognize short
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …

Although the proteins that read the gene regulatory code, transcription factors (TFs), have
been largely identified, it is not well known which sequences TFs can recognize. We have …

The recognition of specific DNA sequences by proteins is thought to depend on two types of
mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily …

The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene
expression. The crystal structure of a complex containing the three zinc fingers from Zif268 …

Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …

Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations
in human cancer. The majority of the mutations occur in the core domain which contains the …

Highlights•Transcription factors can cooperate with each other via multiple mechanisms that
have different specificities and ranges.•Cooperativity can result from direct protein–protein …

The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator
protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by …