Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their
cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …

Recent studies have suggested that exploring the potential mechanisms regulating
ferroptosis vulnerability may contribute to improving the systemic therapeutic efficacy in …

Abstract In mammals, triglyceride (TG), the main form of lipids for storing and providing
energy, is stored in white adipose tissue (WAT) after food intake, while during fasting it is …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Endoplasmic reticulum-associated degradation (ERAD) plays indispensable roles in many
physiological processes; however, the nature of endogenous substrates remains largely …

Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with
lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative …

Cardiovascular disease (CVD) is still the leading cause of death globally, and
atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol …