Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Vascular endothelial growth factor receptor type 2 (VEGFR2, also known as KDR and FLK1)
signalling in endothelial cells (ECs) is essential for developmental and reparative …

VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key
role in the maintenance of vascular integrity. During embryo development, VE-cadherin is …

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-
absorbed lipids are packaged into chylomicrons, which enter the bloodstream through …

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …

Reactive oxygen species (ROS) derived from NADPH oxidase (NOX) and mitochondria play
a critical role in growth factor-induced switch from a quiescent to an angiogenic phenotype …

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple
fundamental cellular signaling cascades. Nrp family members have key functions in VEGF …