Iron is an essential element for the development and functionality of the brain, and
anomalies in its distribution and concentration in brain tissue have been found to be …

Abnormal accumulation of brain iron has been detected in various neurodegenerative
diseases, but the contribution of iron overload to pathology remains unclear. In a group of …

Perturbation of iron distribution is observed in many neurodegenerative disorders, including
Alzheimer's and Parkinson's disease, but the comprehension of the metal role in the …

Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and
genetically heterogeneous group of disorders with progressive extrapyramidal signs and …

Neurodegeneration with brain iron accumulation (NBIA) is a set of neurodegenerative
disorders, which includes very rare monogenetic diseases. They are heterogeneous in …

Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by
pharmacogenetic factors. With genetic studies thus far providing little biological insight or …

Brain iron accumulation is the hallmark of a group of seriously invalidating and progressive
rare diseases collectively denominated Neurodegeneration with Brain Iron Accumulation …

Trace elements, such as iron, copper, manganese, and calcium, which are essential
constituents necessary for cellular homeostasis, become toxic when present in excess …

Mutations in C19orf12 have been identified in patients affected by Neurodegeneration with
Brain Iron Accumulation (NBIA), a clinical entity characterized by iron accumulation in the …

Syndromes with neurodegeneration with brain iron accumulation (NBIA) are a group of
neurodegenerative disorders characterized by abnormalities in brain iron metabolism with …