The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

Aging is associated with specific impairments of learning and memory, some of which are
similar to those caused by hippocampal damage. Studies of the effects of aging on …

Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Epidemiological studies suggest that individuals with greater education or more cognitively
demanding occupations have diminished risk of develo** dementia. We wanted to test …

Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal
neurons during aging. However, the molecular basis for this elevation is not known. The …

Studies demonstrate lasting cognitive impairment in elderly persons after anesthesia and
surgery. We tested the hypothesis that general anesthesia contributes to this cognitive …

The present study tested whether environmental enrichment can reduce age-related spatial
reference memory deficits and alter synaptic protein levels in aged female mice. Female …

There is growing evidence that stress during prenatal and postnatal periods of life can
modify adaptive capacities in adulthoods. The hypothalamo–pituitary–adrenal axis may …

This article examines the functional significance of Ca2+-dependent synaptic plasticity in
relation to compromised memory function during aging. Research characterizing an age …

Executive functions supported by prefrontal cortical (PFC) systems provide essential control
and planning mechanisms to guide goal-directed behavior. As such, age-related alterations …