Neurons are among the largest and most complex cells in the body. Their immense size and
intricate geometry pose many unique cell-biological problems. How is dendritic architecture …

The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations
in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and …

Dendritic spines show rapid motility and plastic morphology, which may mediate information
storage in the brain. It is presently believed that polymerization/depolymerization of actin is …

Myosin II is an actin-binding protein composed of MHC (myosin heavy chain) IIs, RLCs
(regulatory light chains) and ELCs (essential light chains). Myosin II expressed in non …

NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for
neurotransmission and memory. At the cellular level, the effects of activating these receptors …

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system.
There are three distinct subtypes of ionotropic glutamate receptors (GluRs) that have been …

Background: Despite extensive efforts, significant gaps remain in our understanding of
Alzheimer's disease (AD) pathophysiology. Novel approaches using circulating cell-free …

Thyroid hormone (TH) directs seasonal breeding through reciprocal regulation of TH
deiodinase (Dio2/Dio3) gene expression in tanycytes in the ependymal zone of the medio …

purpose. Mertk is a key phagocytic receptor in the immune, male reproductive, and visual
systems. In the retinal pigment epithelium, Mertk is required for the daily ingestion of …

Protein phosphorylation and dephosphorylation are two essential and vital cellular
mechanisms that regulate many receptors and enzymes through kinases and phosphatases …