Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …

Tyr phosphatases are, by definition, enzymes that dephosphorylate phospho‐Tyr (pT yr)
from proteins. This activity is found in several structurally diverse protein families, including …

Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

Phosphatases play key roles in normal physiology and diseases. Studying phosphatases
has been both essential and challenging, and the application of conventional genetic and …

Signaling by signal transducers and activators of transcription (STATs) is controlled at many
levels of the signaling cascade. Protein tyrosine phosphatases (PTPs) regulate STAT …

The human Dep ho sphorylation D atabase (DEPOD) is a manually curated resource that
harbors human phosphatases, their protein and non-protein substrates, dephosphorylation …

Phosphatases are crucial enzymes in health and disease, but the knowledge of their
biological roles is still limited. Identifying substrates continues to be a great challenge. To …

Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune
response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the …

Phosphorylation of serine, threonine and tyrosine plays significant roles in cellular signal
transduction and in modifying multiple protein functions. Phosphoproteins are coordinated …

In higher eukaryotes, the Tyr phosphorylation status of cellular proteins results from the
coordinated action of Protein Tyrosine Kinases (PTKs) and Protein Tyrosine Phosphatases …