NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

In this review we explore innovative approaches in the treatment of hematologic cancers by
combining various therapeutic modalities. We discuss the synergistic potential of combining …

Neddylation, akin to ubiquitination, represents a post‑translational modification of proteins
wherein neural precursor cell‑expressed developmentally downregulated protein 8 …

Abstract Topoisomerases (TOP1, TOP2α, and β) are nuclear enzymes crucial for virtually all
aspects of DNA metabolisms. They also are the targets of important anti-tumor …

DNA− protein crosslinks (DPCs) challenge faithful DNA replication and smooth passage of
genomic information. Our study unveils the cullin E3 ubiquitin ligase Rtt101 as a DPC repair …

Hyperactivation of ribosome biogenesis (RiBi) drives cancer progression, yet the role of RiBi-
associated proteins (RiBPs) in breast cancer (BC) is underexplored. In this study, we …

DNA–protein crosslinks (DPCs) represent a unique and complex form of DNA damage
formed by covalent attachment of proteins to DNA. DPCs are formed through a variety of …

The ATP-dependent molecular chaperone Cdc48 (in yeast) and its human counterpart p97
(also known as VCP), are essential for a variety of cellular processes, including the removal …

Transcription factors play key roles in development and disease by controlling gene
expression. Forkhead box A1 (FOXA1), is a pioneer transcription factor essential for mouse …