Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped
nanoparticles with diverse biological function, diagnostic potential, and therapeutic …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Chromatin provides both a means to accommodate a large amount of genetic material in a
small space and a means to package the same genetic material in different chromatin states …

Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …

Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many
nuclear processes, but local dynamics of the nucleosome and its modulation by DNA …

Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …

Access to DNA within nucleosomes is required for a variety of processes in cells including
transcription, replication and repair. Consequently, cells encode multiple systems that …

Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized
products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine …