Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein
tyrosine kinases which, when activated, initiate the formation of protein complexes that …

Ligand activation of the epidermal growth factor receptor (EGFR) leads to its rapid
internalization and eventual delivery to lysosomes. This process is thought to be a …

Protein tyrosine kinases (PTKs) coordinate a broad spectrum of cellular responses to
extracellular stimuli and cell–cell interactions during development, tissue homeostasis, and …

Non-receptor type of protein-tyrosine kinase Syk contains 2 Src homology 2 (SH2) domains
in tandem and multiple autophosphorylation sites. Syk is activated upon binding of tandem …

The signaling events downstream of integrins that regulate cell attachment and motility are
only partially understood. Using osteoclasts and transfected 293 cells, we find that a …

The proto‐oncogenic protein c‐Cbl was discovered as the cellular form of v‐Cbl, a retroviral
transforming protein. This was followed over the years by important discoveries, which …

The activation of signalling pathways by ligand engagement with transmembrane receptors
is responsible for determining many aspects of cellular function and fate. While these …