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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …
host cell factors have been implicated in its formation. In particular, recent results have …
The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding
Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
We studied human immunodeficiency virus, type 1 (HIV-1) integrase (IN) complexes derived
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …
Menin critically links MLL proteins with LEDGF on cancer-associated target genes
Menin displays the unique ability to either promote oncogenic function in the hematopoietic
lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular …
lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular …
Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions
Background: Sera of patients with atopic dermatitis (AD) were found to have autoantibodies
that reacted with tissue culture cell substrates in immunohistochemistry to display a …
that reacted with tissue culture cell substrates in immunohistochemistry to display a …
Cellular co-factors of HIV-1 integration
B Van Maele, K Busschots, L Vandekerckhove… - Trends in biochemical …, 2006 - cell.com
To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency
virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this …
virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this …
Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts
We isolated a clone encoding a protein from a human lens epithelial cell (LEC) cDNA library
with antibody (Ab) from a cataract patient and named it “lens epithelium-derived growth …
with antibody (Ab) from a cataract patient and named it “lens epithelium-derived growth …
[HTML][HTML] Tumor-associated antigen arrays for the serological diagnosis of cancer
The recognition that human tumors stimulate the production of autoantibodies against
autologous cellular proteins called tumor-associated antigens (TAAs) has opened the door …
autologous cellular proteins called tumor-associated antigens (TAAs) has opened the door …
Integrase, LEDGF/p75 and HIV replication
HIV integrates a DNA copy of its genome into a host cell chromosome in each replication
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …
Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis
T Daniels, J Zhang, I Gutierrez, ML Elliot… - The …, 2005 - Wiley Online Library
BACKGROUND Cancer patients produce autoantibodies to self‐proteins called tumor‐
associated antigens (TAA). These autoantibodies represent potentially valuable tools for …
associated antigens (TAA). These autoantibodies represent potentially valuable tools for …