Sensing sound: Cellular specializations and molecular force sensors

X Qiu, U Müller - Neuron, 2022 - cell.com
Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Physics of mechanotransduction by Piezo ion channels

M Young, AH Lewis, J Grandl - Journal of General Physiology, 2022 - rupress.org
Piezo ion channels are sensors of mechanical forces and mediate a wide range of
physiological mechanotransduction processes. More than a decade of intense research has …

Ultrafast underwater self-healing piezo-ionic elastomer via dynamic hydrophobic-hydrolytic domains

Z Kong, EK Boahen, DJ Kim, F Li, JS Kim… - Nature …, 2024 - nature.com
The development of advanced materials capable of autonomous self-healing and
mechanical stimulus sensing in aquatic environments holds great promise for applications in …

Force from filaments: the role of the cytoskeleton and extracellular matrix in the gating of mechanosensitive channels

YC Chuang, CC Chen - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion
channels that transduce mechanical stimuli with high sensitivity and speed. This conversion …

Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction

MB Goodman, ES Haswell, V Vásquez - Journal of General Physiology, 2023 - rupress.org
This Viewpoint, which accompanies a Special Issue focusing on membrane
mechanosensors, discusses unifying and unique features of both established and emerging …

An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity

R Das, LC Lin, F Català-Castro, N Malaiwong… - Science …, 2021 - science.org
A repetitive gait cycle is an archetypical component within the behavioral repertoire of many
animals including humans. It originates from mechanical feedback within proprioceptors to …

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

P Hehlert, T Effertz, RX Gu, B Nadrowski… - Nature …, 2025 - nature.com
The sensation of mechanical stimuli is initiated by elastic gating springs that pull open
mechanosensory transduction channels. Searches for gating springs have focused on force …

Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions

L Rolband, D Beasock, Y Wang, YG Shu… - Computational and …, 2022 - Elsevier
Abstract The International Society of RNA Nanotechnology and Nanomedicine (ISRNN)
serves to further the development of a wide variety of functional nucleic acids and other …

Simulation and machine learning methods for ion-channel structure determination, mechanistic studies and drug design

Z Zhu, Z Deng, Q Wang, Y Wang, D Zhang… - Frontiers in …, 2022 - frontiersin.org
Ion channels are expressed in almost all living cells, controlling the in-and-out
communications, making them ideal drug targets, especially for central nervous system …

Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome

Q Jia, Y Yang, X Chen, S Yao, Z Hu - Respiratory Research, 2022 - Springer
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating
respiratory disorder with high rates of mortality and morbidity, but the detailed underlying …