Secreted immunomodulatory viral proteins as novel biotherapeutics

A Lucas, G McFadden - The Journal of immunology, 2004 - journals.aai.org
Many viruses have learned to evade or subvert the host antiviral immune responses by
encoding and expressing immunomodulatory proteins that protect the virus from attack by …

[HTML][HTML] Chemokine binding proteins: An immunomodulatory strategy going viral

V González-Motos, KA Kropp… - Cytokine & growth factor …, 2016 - Elsevier
Chemokines are chemotactic cytokines whose main function is to direct cell migration. The
chemokine network is highly complex and its deregulation is linked to several diseases …

Human cytomegalovirus immediate-early 2 protein IE86 blocks virus-induced chemokine expression

RT Taylor, WA Bresnahan - Journal of virology, 2006 - Am Soc Microbiol
The effect of human cytomegalovirus (HCMV) gene expression on cytokine (beta interferon)
and chemokine (RANTES, MIG, MCP-2, MIP-1α, and interleukin-8) expression was …

Targeting chemokines: Pathogens can, why can't we?

AEI Proudfoot, P Bonvin, CA Power - Cytokine, 2015 - Elsevier
Chemoattractant cytokines, or chemokines, are the largest sub-family of cytokines. About 50
distinct chemokines have been identified in humans. Their principal role is to stimulate the …

Immune modulation by virus-encoded secreted chemokine binding proteins

H Heidarieh, B Hernáez, A Alcamí - Virus research, 2015 - Elsevier
Chemokines are chemoattractant cytokines that mediate the migration of immune cells to
sites of infection which play an important role in innate and adaptive immunity. As an …

Regulation of chemokine function: the roles of GAG-binding and post-translational nitration

S Thompson, B Martínez-Burgo, KM Sepuru… - International journal of …, 2017 - mdpi.com
The primary function of chemokines is to direct the migration of leukocytes to the site of injury
during inflammation. The effects of chemokines are modulated by several means, including …

How microorganisms avoid phagocyte attraction

J Bestebroer, CJC De Haas… - FEMS microbiology …, 2010 - academic.oup.com
Microorganisms have developed several mechanisms to modulate the host immune system
to increase their survival and propagation in the host. Their presence in the host is not only …

Glycoprotein G from pseudorabies virus binds to chemokines with high affinity and inhibits their function

A Viejo-Borbolla, A Munoz… - Journal of general …, 2010 - microbiologyresearch.org
Pseudorabies virus (PRV), also known as suid herpesvirus, is the aetiological agent of
Aujeszky's disease in swine. In other animals, except higher-order primates, PRV infection is …

AC‐terminal CXCL 8 peptide based on chemokine–glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation

B Martínez‐Burgo, SL Cobb, E Pohl, D Kashanin… - …, 2019 - Wiley Online Library
Leucocyte recruitment is critical during many acute and chronic inflammatory diseases.
Chemokines are key mediators of leucocyte recruitment during the inflammatory response …

Inhibition of intimal hyperplasia in transgenic mice conditionally expressing the chemokine-binding protein M3

R Pyo, KK Jensen, MT Wiekowski, D Manfra… - The American journal of …, 2004 - Elsevier
Chemokines have been implicated in the pathogenesis of a wide variety of diseases. This
report describes the generation of transgenic mice that conditionally express M3, a …